Essential Panama City Travel Guide: What to See & Do

Panama City is a destination shaped by movement, trade, and striking contrasts. Located at the Pacific entrance to the Isthmus of Panama, the capital combines tropical landscapes and relaxed Latin American energy with modern towers, international businesses, and the engineering landmark that transformed global shipping.

Explore Panama City’s Colonial Heritage

The city’s historic character is most visible in Casco Viejo, the UNESCO-listed quarter founded in 1673 after the original settlement, Panama Viejo, was destroyed by Henry Morgan’s attack. Narrow streets, defensive walls, colorful facades, ornate balconies, and leafy plazas create an atmospheric setting where restored buildings stand alongside weathered ruins.

Several historic churches reflect Panama City’s colonial and religious heritage, including:

• Iglesia San José
• La Merced
• San Francisco de Asís
• The Metropolitan Cathedral

Discover Panama Viejo and the Panama Canal

Panama Viejo offers a different perspective on the capital’s past. Its archaeological remains, including the old cathedral tower, recall the city’s early role as a vital link between South American wealth and Europe.

At Miraflores Locks, visitors can watch the Panama Canal in operation as ships pass through changing water levels and massive gates. Nearby, the Biomuseo explores how the formation of the isthmus altered biodiversity and connected continents.

Enjoy Food, Nightlife, and City Views

For travelers searching for things to do in Panama City, the experience extends beyond historic attractions. Casco Viejo is also the center of the capital’s creative food and nightlife scene, with options ranging from seafood and ceviche to inventive tasting menus and rooftop venues overlooking the skyline.

With tropical greenery, ocean views, and layers of Spanish, American, and global influence, Panama City offers one of Central America’s most distinctive urban experiences.